Conceptual Frame

The hypothesis is that the fasting mimicking diet can trigger, and sustain, autophagy in the body. In turn, autophagy can increase both healthspan and lifespan.

How does autophagy increase healthspan and lifespan?

Autophagy exists within all eukaryote cells, it regulates a homeostatic process that has been preserved in evolution for 3 billion years.

Autophagy can promote cellular health by removing all unneeded or dysfunctional components, such as broken proteins found in the cell lysosome.

Autophagy can potentially prevent diseases such as cancer, and mitochondrial related disease.

As a metabolic state, autophagy works along-side glucogenic and ketogenic metabolic processes.

How can a person reproducibly switch into an autophagic metabolic state?

In short, if you don't eat protein, your body will be signalled to start the process of recycling broken proteins.

Measuring the Glucose Ketone Index is the best known method for measuring Autophagy.

There are a lot of people sharing their experiences with the fasting mimicking diet. Here are a few:

1. Google Sheet - Fasting Mimicking Diet - Quantified Bob
2. Google Sheet - Fasting Mimicking Diet - B Richardson
3. Siim Land - Ketogenic Fasting Mimicking Diet How-to Guide

What aspects of homeostasis is Autophagy involed with?

What are the limitations and open questions about Autophagy?

Benefits

The following table is provided in a great article from Perfect Keto about the fasting mimicking diet.